Additional Info

• ECTS credits: 6
• University: University of L'Aquila
• Semester: 3
• Lecturer 1: Pasquale Palumbo
• Objectives:

   

  Systems biology is an emerging research area, which aims to investigate mathematical models helping to understand the dynamic interactions occurring within and between cells. This course provides the mathematical tools to model and analyze gene transcription networks and focuses the attention on the case study of cell cycle modeling.

• Topics:

   

  Transcription networks. The rules of transcription: promoters and transcriptor factors, activators and repressors. Graph properties of a transcriptor network. ODE approach: dynamics of gene regulation. Network motifs emerging by comparison to randomized networks. Possible functions of network motifs in transcription networks. Methods to infer information from data: the state observer approach and application to gene transcription networks. Biological examples from the E. Coli. Cell cycle models: focus on the budding yeast. The G1/S transition: the critical size and the budding period. Heterogeneous population models and age/protein distribution functions.